Invitrogen

CGRP Monoclonal Antibody (5)

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Antibody Testing Data (1)
Published Figures (2)

CGRP Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 3

CGRP Antibody (ABS 026-05-02) in IHC (P)

Immunohistochemical analysis of CGRP alpha in paraffin-embedded rat tissue using a CGRP alpha monoclonal antibody (Product # ABS 026-05-02) after overnight incubation at a dilution of 1:400 in 1% BSA/PBS.

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Product Details

ABS 026-05-02

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent

View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent

Product Specifications

Species Reactivity

Human, Rat

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

Immunogen

Synthetic peptide corresponding to residues 19-37 of human alpha-CGRP.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.02 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

15mM sodium azide

Storage conditions

4° C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1073000

Product Specific Information

ABS 026-05-02 detects CGRP alpha in human and rat samples. ABS 026-05-02 binds human alpha-CGRP. Based on inhibition ELISA, this antibody shows full cross-reactivity with rat alpha-CGRP and about about 50% cross-reactivity with human beta-CGRP. Cross-reactivity with coated rat alpha-CGRP is low (8%) and there is no cross-reaction with human amylin.

ABS 026-05-02 has been successfully used in ELISA and immunohistochemistry procedures.

Target Information

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A putative anti-inflammatory role for TRPM8 in irritable bowel syndrome-An exploratory study.

Neurogastroenterology and motility

Peiris M,Weerts ZZRM,Aktar R,Masclee AAM,Blackshaw A,Keszthelyi D

ABS 026-05-02 was used in ELISA, Immunohistochemistry (Paraffin) to show that TRPM8 immunoreactivity is colocalized with immune cells predominantly of the dendritic cell lineage, in close approximation to nerve endings, and TRPM8 protein and mRNA expression was increased in IBS patients compared to controls (p < 0.001).

Wed Sep 01 00:00:00 EDT 2021

UEG Week 2020 Poster Presentations.

United European gastroenterology journal

No authors listed

ABS 026-05-02 was used in Immunohistochemistry to evaluate the role of serum adipokines as possible biomarkers in Crohn’s disease.

Thu Oct 01 00:00:00 EDT 2020

A novel role for the extracellular matrix glycoprotein-Tenascin-X in gastric function.

The Journal of physiology

Aktar R,Peiris M,Fikree A,Eaton S,Kritas S,Kentish SJ,Araujo EJA,Bacarin C,Page AJ,Voermans NC,Aziz Q,Blackshaw LA

ABS 026-05-02 was used in Immunohistochemistry to report the first role for TNX in gastric function which included the result of TNXB-defifient patients experiencing significantly greater symptoms of reflux, indigestion and abdominal pain.

Fri Mar 01 00:00:00 EST 2019

Esophageal mucosal innervation in functional heartburn: Closer to healthy asymptomatic subjects than to non-erosive reflux disease patients.

Neurogastroenterology and motility

Nikaki K,Woodland P,Lee C,Ghisa M,Marinelli C,Savarino E,Sifrim D

ABS 026-05-02 was used in ELISA, Immunohistochemistry (Paraffin) to study the Esophageal mucosal innervation in functional heartburn.

Sun Sep 01 00:00:00 EDT 2019

The extracellular matrix glycoprotein tenascin-X regulates peripheral sensory and motor neurones.

The Journal of physiology

Aktar R,Peiris M,Fikree A,Cibert-Goton V,Walmsley M,Tough IR,Watanabe P,Araujo EJA,Mohammed SD,Delalande JM,Bulmer DC,Scott SM,Cox HM,Voermans NC,Aziz Q,Blackshaw LA

ABS 026-05-02 was used in Immunohistochemistry to study the effect of Tenascin-X on neural function.

Sat Sep 01 00:00:00 EDT 2018

Superficial Esophageal Mucosal Afferent Nerves May Contribute to Reflux Hypersensitivity in Nonerosive Reflux Disease.

Gastroenterology

Woodland P,Shen Ooi JL,Grassi F,Nikaki K,Lee C,Evans JA,Koukias N,Triantos C,McDonald SA,Peiris M,Aktar R,Blackshaw LA,Sifrim D

ABS 026-05-02 was used in Immunohistochemistry to study the distribution of mucosal nerve fibers in patients with nonerosive reflux disease, erosive reflux disease, and Barrett's esophagus, and compare the results with those of healthy subjects.

Wed Nov 01 00:00:00 EDT 2017

Distinct afferent innervation patterns within the human proximal and distal esophageal mucosa.

American journal of physiology. Gastrointestinal and liver physiology

Woodland P,Aktar R,Mthunzi E,Lee C,Peiris M,Preston SL,Blackshaw LA,Sifrim D

ABS 026-05-02 was used in Immunohistochemistry to show that mucosal barrier integrity is similar in proximal and distal esophagus but proximal mucosal afferent nerves are in a more superficial location.

Sun Mar 15 00:00:00 EDT 2015

Distinct afferent innervation patterns within the human proximal and distal esophageal mucosa.

American journal of physiology. Gastrointestinal and liver physiology

Woodland P,Aktar R,Mthunzi E,Lee C,Peiris M,Preston SL,Blackshaw LA,Sifrim D

Sun Mar 15 00:00:00 EDT 2015

Bioinformatics

Protein Aliases: Alpha-type CGRP; Calcitonin; calcitonin 1; Calcitonin gene-related peptide 1; Calcitonin gene-related peptide I; calcitonin-related polypeptide alpha; calcitonin/calcitonin-related polypeptide, alpha; CGRP-I; katacalcin; MGC126648; RAT calcitonin

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Gene Aliases: Cal1; CAL6; Calc; CALC1; CALCA; calcitonin; CGRP; CGRP-I; CGRP1; CT; KC; PCT; RATCAL6

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UniProt ID: (Human) P01258, (Rat) P01257

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Entrez Gene ID: (Human) 796, (Rat) 24241

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Function(s)

hormone activity protein binding calcitonin receptor binding identical protein binding receptor binding neuropeptide hormone activity protein complex binding peptide hormone

Process(es)

Performance Guarantee

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CGRP Monoclonal Antibody (5)

CGRP Antibody (ABS 026-05-02) in IHC (P)

Product Details

ABS 026-05-02

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

ELISA (ELISA)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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